Lyon is a town in Coahoma County, Mississippi, United States. The population was 350 at the 2010 census.
Lyon is located in east-central Coahoma County. It is bordered to the west and south by the city of Clarksdale, the county seat.
According to the United States Census Bureau, the town has a total area of 0.46 square miles (1.2 km), all land.
As of the census of 2000, there were 418 people, 170 households, and 121 families residing in the town. The population density was 897.0 people per square mile (343.4/km²). There were 177 housing units at an average density of 379.8 per square mile (145.4/km²). The racial makeup of the town was 74.40% White, 25.12% African American and 0.48% Asian.
There were 170 households out of which 32.9% had children under the age of 18 living with them, 57.6% were married couples living together, 11.8% had a female householder with no husband present, and 28.8% were non-families. 28.2% of all households were made up of individuals and 14.1% had someone living alone who was 65 years of age or older. The average household size was 2.45 and the average family size was 3.00.
In the town, the population was spread out with 23.4% under the age of 18, 8.9% from 18 to 24, 26.3% from 25 to 44, 23.9% from 45 to 64, and 17.5% who were 65 years of age or older. The median age was 41 years. For every 100 females, there were 95.3 males. For every 100 females age 18 and over, there were 91.6 males.
The median income for a household in the town was $34,375, and the median income for a family was $56,042. Males had a median income of $43,750 versus $23,611 for females. The per capita income for the town was $20,646. About 15.0% of families and 21.0% of the population were below the poverty line, including 36.9% of those under age 18 and 4.7% of those age 65 or over.