Houston is a city in and one of two county seats of Chickasaw County, in northern Mississippi. The population was 3,623 at the 2010 census.
Houston is located west of the center of Chickasaw County. Mississippi Highway 8 passes through the city, leading east 29 miles (47 km) to Aberdeen and west 18 miles (29 km) to Calhoun City. Mississippi Highway 15 bypasses the city to the west, crossing Highway 8 within a western extension of the city limits. Highway 15 leads north 26 miles (42 km) to Pontotoc and south 27 miles (43 km) to Mathiston. The Natchez Trace Parkway passes about 3 miles (5 km) east of the city center; the Trace followed an ancient Native American trail.
According to the United States Census Bureau, the city has a total area of 7.39 square miles (19.15 km), of which 7.38 square miles (19.11 km) is land and 0.02 square miles (0.05 km), or 0.25%, is water.
As of the census of 2000, there were 4,079 people, 1,589 households, and 1,088 families residing in the city. The population density was 537.4 people per square mile (207.5/km²). There were 1,721 housing units at an average density of 226.8 per square mile (87.5/km²). The racial makeup of the city was 59.89% White, 36.58% African American, 0.27% Native American, 0.17% Asian, 0.12% Pacific Islander, 2.70% from other races, and 0.27% from two or more races. Hispanic or Latino of any race were 5.12% of the population.
There were 1,589 households out of which 33.5% had children under the age of 18 living with them, 44.6% were married couples living together, 19.4% had a female householder with no husband present, and 31.5% were non-families. 29.1% of all households were made up of individuals and 15.0% had someone living alone who was 65 years of age or older. The average household size was 2.49 and the average family size was 3.06.
In the city, the population was spread out with 26.6% under the age of 18, 10.3% from 18 to 24, 26.9% from 25 to 44, 19.5% from 45 to 64, and 16.8% who were 65 years of age or older. The median age was 35 years. For every 100 females, there were 88.3 males. For every 100 females age 18 and over, there were 83.6 males.
The median income for a household in the city was $23,709, and the median income for a family was $31,979. Males had a median income of $27,214 versus $22,000 for females. The per capita income for the city was $12,482. About 22.6% of families and 21.2% of the population were below the poverty line, including 17.8% of those under age 18 and 28.0% of those age 65 or over.